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Relative gene expression of Atrogin-1 ( Fbxo32 ) and MuRF-1 ( Trim63 ) was quantified using the 2 CT method, normalized to the housekeeping gene GAPDH

Known to regulate gene expression and protein synthesis, epithalon has been found to suppress both the CCl11 and HMGB1 genes, thereby increasing the lifespan of test subjects [4]

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51 SajidI.AhmadS.EmadS.BatoolZ.KhaliqS.AnisL.et al (2017)

Importantly, KRAS-dependent NSCLC cells that were hypersensitive to LDHB/SLC7A11 inhibition (A549, H460, H2122, H838, H2009, KP) exhibited high levels of NRF2 or NRF2 score based on prior studies [57, 58], whereas the outliers (H358, H23, and Calu-1), in which LDHB KD failed to sensitize the cells to Erastin or RSL3, are characterized by low NRF2 levels

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