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Since nicotinamide boosting could increase the production of oxyradicals from the ETC, we treated the hippocampal neurons with EGCG to control an oxidative redox state that causes ROS overproduction

Clinical features of SJS/TEN can mimic other dermatologic diseases, including erythema multiforme, reactive infectious mucocutaneous eruption, generalized bullous fixed drug eruption, staphylococcal scalded skin syndrome, pemphigus vulgaris, and acute graft versus host disease, among others (Table 2)

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Studies demonstrate rapid systemic uptake and targeted activity at endothelial and fibroblastic levels, implicating it in nitric oxide modulation, collagen synthesis, and vascular repair