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In contrast, this area is a positively charged flat surface in GPx4 (Figure 4c) and has been considered to be involved in the efficient binding of complex lipid molecules at the active site 21

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Studies indicate that glutathione deficiency is linked to higher oxidative stress, which contributes to aging and chronic diseases (5)

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Hepatocytes treated with 111 M for 4 hours experience an approximate 20% decrease in both cytoplasmic and mitochondrial GSH 39