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doi: 10.1210/en.2004-1286

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Critically, FOXO4-DRI does not predispose healthy cells to DNA damage or sensitize normal tissues to chemotherapy when administered prior to or during treatment

Additionally, IGF-1 can induce the expression of vascular endothelial growth factor (VEGF) via hypoxia-inducible factor 1 (HIF-1), promoting angiogenesis, which is critical for tumor growth and metastasis [8, 9]