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111 The suppressive effects of PP have not been consistently replicated, and are relatively modest, even at high doses

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References Risbud MV, Schaer TP, Shapiro IM: Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord

The underlying mechanisms are often attributed to neuroinflammation, disruption of the gut-brain axis, and reduced sleep quality and duration, which are frequently cited as triggers of brain fog