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CDVs have been reported to offer higher production yields and exhibit therapeutic efficacy comparable to EVs 12,13

For long-term use in humans, implantable light probes must be operable and biocompatible as well as there must be efficient delivery, retainment, and expression of opsins in vivo to target cells with minimal adverse immune responses

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The goiter of Hashimoto's thyroiditis may remain unchanged for decades(37), but usually it gradually increases in size