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This approach can simplify study protocols and improve consistency across experiments

For in vivo pharmacokinetic analysis, male Sprague-Dawley rats weighing 250 g were cannulated in the right jugular vein

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[28] Although not relevant at clinical dosages, bromantane has been found to produce anticholinergic effects, including both antimuscarinic and antinicotinic actions, at very high doses in animals, and these effects are responsible for its toxicity (that is, LD 50 ) in animals

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