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Common side effects associated with B12 supplementation include: Local injection site reactions (for intramuscular preparations): Pain, redness, or swelling at the injection site Mild bruising or tenderness Itching localised to the injection area These reactions are usually self-limiting and resolve within 2448 hours

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72 More serious reactions are rare, but you should seek immediate medical attention if you develop hives, swelling of the lips, throat, or tongue, or difficulty breathing