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doi: 10.1016/s1535-6108(03)00050-3 11 YangWSStockwellBR

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Pathophysiology and treatment of cerebral edema in traumatic brain injury

CHAC1 degrades GSH, leading to GSH depletion and oxidative stress

Early pharmacology work described it as a selective growth-hormone secretagogue, with GH release and little ACTH or cortisol signal in the foundational studies