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For example, proton pump inhibitors (PPIs) and H2 receptor antagonists, commonly used to treat gastroesophageal reflux disease (GERD), can reduce the absorption of vitamin B12 and may necessitate adjustments in the dosing of methylcobalamin

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"Folate and cobalamin in psychiatric illness"

There is a second pathway that breaks down levodopa, via the enzyme catechol-O-methyltransferase (COMT)

Throughout our menstrual periods, we experience both physical and emotional changes