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Description

Ferric iron (Fe 3+ ) is stored within ferritin in the cytoplasm, whereas Fe 2+ for ferroptosis induction is either imported via CD44 from the extracellular compartment [22] or provided via lysosomal ferritin degradation and subsequent reduction [23]

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& Yamamoto, B

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Ferroptosis in lung cancer: from molecular mechanisms to prognostic and therapeutic opportunities

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Their specific role depends on the formulation

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