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PMID 28035768.

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A 2025 matched-cohort study found men who started testosterone therapy had significantly higher rates of tendon tears and repairs at one and two years compared to controls, a pattern the authors attributed to testosterone's effect on tendon biomechanics outpacing the tissue's regenerative capacity Sherman et al

It stands out from other peptides because of the wide variety of biological areas it has been studied in, ranging from muscle to connective tissue to gastrointestinal environments

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These small changes are easy to attribute to other factors like diet, stress, or tolerance, when the real culprit is sitting in your refrigerator with a past-due label