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For example, the mechanosensitive ion channel Piezo1 is markedly upregulated in the colonic mucosa of patients with UC (Zhou et al., 2025a), and its excessive activation exacerbates epithelial injury, in part by promoting ferroptosis (He H
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Comp Biochem Physiol 116B:217221 Carney Almroth B, Albertsson E, Sturve J, Frlin L (2008) Oxidative stress, evident in antioxidant defences and damage products, in rainbow trout caged outside a sewage treatment plant
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Symptoms of B12 deficiency include: Fatigue Low mood or personality/mood changes Irritability Lethargy Headaches Palpitations Loss of appetite Pale yellow tint to the skin A feeling of pins and needles (paraesthesia) Poor memory Impaired cognitive performance Depression Weakness Impaired digestion Inflammation Gastrointestinal lesions Neurological damage Since B12 is primarily found in animal products, any change in ones diet that leads to a decrease in the consumption of such products such as a vegan , vegetarian, or low-fat diet can increase the chance of a person developing a B12 deficiency
