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Sonoyama, W

World Psychiatry 24 , 227239 (2025)

Heres my game plan: Test for intrinsic factor antibodies if my doctor offers this Try high-dose sublingual B12 (5000mcg daily) for 8 weeks as a test If my B12 stays below 400 pg/mL, go straight to injections Calculate the cost difference to justify the investment The 10% Rule If youre absorbing less than 10% of your oral B12 (you can estimate this by comparing your supplement dose to your blood response), weekly shots often cost less than daily high-dose pills

However, changes in GABAergic, cholinergic, noradrenergic, and serotonergic neurotransmission have also been identified as promoters of psychotic symptoms (11, 12)

Because superoxide cannot cross the membrane of mitochondria, it reacts with water to form hydrogen peroxide, which is very susceptible to spontaneously passing out of the membrane [27]

Rabin et al., 2015)