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At the hair bulb, melanocyte stem cells differentiate into melanocytes i.e., cells that can produce melanin

Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]

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In conclusion, in a meta-analysis of four studies, which included 259 AD patients and 307 healthy controls, it was observed that AD patients had significantly lower serum vitamin E levels than the control group (standardized mean difference: -1.08, 95% CI: 1.80 to 0.36) (81)

However, challenges remain in addressing issues related to targeting, safety, and delivery efficiency