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These issues can make even the simplest recovery feel like a significant obstacle
That is a very different statement from they do nothing. It means: The mechanistic rationale is real
When cancer cells relied on GSH for cysteine acquisition, they were more sensitive to GGsTop 43 , a putative inhibitor of GGT activity (Fig
Structure-activity relationships in beta-defensin peptides
When cyp2e1 knockout mice that lack the ability to produce the CYP2E1 enzyme were challenged with acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this CYP is the principal enzyme responsible for the metabolic conversion of the drug acetaminophen to its active hepatotoxic metabolite NAPQI (Figure 2)
Acknowledgements This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (NRF-2021R1A2C1005368), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (RS-2023-00217123), and the Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program (KGM5192423 and KGM9942522)
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