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Mechanistically, USP7-mediated deubiquitination of H2BK120ub facilitates PRMT6-dependent deposition of the repressive mark H3R2me2a, concomitant with the exclusion of activating H3K4me3

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UPP1 facilitates the conversion of 5-FU into its active compounds, thereby enhancing its inhibitory effect on thymidylate synthase

Activated microglia release nitric oxide and other mediators that, when combined with superoxide, form peroxynitrite, a highly reactive species capable of damaging proteins, lipids, and DNA

Isolation of primary hepatocytes Primary mouse hepatocytes were obtained using a modified version of a two-step collagenase perfusion technique described by Seglen [28]

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