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Reported TB-500 side effects include fatigue, headaches, injection-site reactions, and appetite changes, but human safety research is very limited

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, Jedlitschky G., Buchholz U., et al

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doi: 10.1016/j.fct.2025.115603 5 Pal SinghMPal KhaketTBajpaiVKAlfarrajSKimS-GChenLet al

Alternatively, traditional wet signatures remain valid in healthcare settings