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Patients taking metformin, those with gastrointestinal symptoms, older adults, or those with restricted diets should discuss B12 monitoring and potential supplementation with their GP
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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure
139,140 Besides SIRT3-mediated deacetylation, SIRT5-dependent desuccinylation improves ROS detoxification via increasing SOD1 activity
April 2026
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