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As of 1998, the FDA has required that all food manufacturers fortify enriched grain products with folic acid to reduce the risk of congenital neural tube defects

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Studies of ergogenic supplements find 12 to 58 percent contamination rates, 30 percent containing incorrect amino acid sequences, and 65 percent exceeding safe endotoxin thresholds

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Encourage patients to plan treatments at least two weeks before significant events to avoid visible bruising

Rare adverse events by definition appear infrequently, but their severity justifies detailed review before any patient or clinician considers use