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even if the rats were orally administered to their maximum dose (1,600 mg/kg/d), and no adverse reactions occurred (Schauss et al., 2011

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Another study showed 3 days of creatine increased total body water and extracellular body water and intracellular body water

Consistent with this effect we report here the induction of -GCS-HS, the catalytic subunit of the rate limiting enzyme in GSH biosynthesis which determines a greater GSH biosynthetic capacity of mucosa 7 days after TNBS treatment

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