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To address this question, we mutated Tyr110 in the CPYS-motif of ScGrx7 as a candidate residue that might contribute to the glutathione activator site (see Discussion for details) and performed a preliminary study with wild-type ScGrx7 as a control

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Consequently, mitochondrial dysfunction has been identified as a central contributor to the onset and progression of various cardiovascular diseases, including HF, myocardial ischemia/reperfusion (I/R) injury, and atherosclerosis