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Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency

Since glutamate synaptic transmission is known to involve receptors that reside on dendritic spines, neurons were probed for excitatory synaptic transmission by staining for the glutamatergic presynaptic marker Vesicular Glutamate Transporter 1 (VGLUT1) (Balschun et al

Above mentioned therapies may resolve neurological deficits and reduce pain (although in many cases insufficient), but they do not lead to repair of the degenerated IVD