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It is worth dwelling on why the wound-chamber design is methodologically valuable, because it is what elevates the strongest reports above a simple observation

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A 2015 review in BioMed Research International, the most-cited summary of GHKs biology, describes the peptide stimulating both the synthesis and the breakdown of collagen and glycosaminoglycans, while nudging the metalloproteinases and their inhibitors in tandem

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Further mechanistic studies suggest that the cardioprotective effects of APS may be mediated by the regulation of the PI3K/Akt/mTOR signaling pathway, which is essential for maintaining cardiomyocyte survival, regulating autophagy, and inhibiting apoptosis (Luo et al., 2014)