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[18] Endogenous vitamin B 12 becomes inactive when exposed to hydrogen cyanide and nitric oxide in cigarette smoke

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However, not all xenobiotics (including drugs) are conjugated/inactivated by this pathway ( The mercapturic acid pathway ( Figure 1 ) involves the conjugation of the tripeptide, GSH, to xenobiotics (including drugs) to render them more hydrophilic and facilitate their elimination

When glutathione is paired with vitamin C, the combination becomes even more effective at fighting oxidative stress