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Skin reactions, including pruritus, erythema, and red spots, were also observed in the placebo group

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In this assay, GRXs first catalyse the reduction of the disulfide in HED with GSH as electron donor, leading to -mercaptoethanol (-ME) and glutathionylated -ME (-ME-SG), the latter serving as a substrate for the de-glutathionylation reaction 42

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