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Pregnancy and breastfeeding are clear contraindications - we lack sufficient safety data on high-dose IV administration during these times

HC B cells (n = 6) were cultured in 20% HC or SLE serum supplemented with LPX-1 for 72 hours, and plasmacytoid dendritic cells (pDC) (n = 3) were cultured for 24 hours, the level of IgG was assessed by ELISA and type I IFNs by flow cytometry individually

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Kenneth Walker et al., 3rd ed., Butterworths, 1990

Acta 1842, 24032412