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Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications

Milk thistle provides complementary liver support, making this a genuinely synergistic formula rather than a standalone single-ingredient product

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Abbreviations BHA: butylated hydroxyanisole BHT: butylated hydroxytoluene MAPKs: mitogen-activated protein kinases NF-: nuclear factor kappa B ROS: reactive oxygen species Declarations Acknowledgement The authors acknowledged the technical assistance of Prof

L., Bonilla, M., Gladyshev, V

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