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Modulation of nitric oxide synthase (NOS) isoforms by 1,25(OH) 2 D 3 observed in our study aligns with previous findings suggesting that vitamin D plays a significant role in regulating vascular homeostasis and reducing oxidative stress [14, 66, 67]

doi:10.5483/BMBRep.2019.52.1.290 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA

Supplementation is unnecessary if parenteral therapy repletes serum levels, but individual assessment is advised

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The ischemic core, the region directly deprived of blood flow, suffers irreversible damage within minutes