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Effect of study bias, publication bias, and small-study effects In all analyses, the pooled estimated SMDs for the subgroups of studies deemed to have low bias was within the 95% CI of the overall (Table 4), suggesting the impact of studies with higher bias was small

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In particular, the PI3K/AKT axis converts phosphatidylinositol-4,5-bisphosphate (PIP 2 ) to phosphatidylinositol 3,4,5-trisphosphate (PIP 3 )

In the early stages of RA, bone marrow edema is a common finding at the spot of subchondral bone in humans, 71 and aberrant transforming growth factor- (TGF-) in the subchondral bone is involved at the onset of RA joint destruction in animal models 72 (Fig