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Abstract A novel core-shell DNA self-assembly catalyzed by thiol-disulfide exchange reactions was proposed, which could realize GSH-initiated hybridization chain reaction (HCR) for signal amplification and molecules gathering

Ketika jumlah radikal bebas lebih banyak dalam tubuh dibandingkan antioksidan, terjadi kerusakan sel dalam tubuh

This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells

In this regard, different studies have suggested a positive effect of metformin on HDL functionality

2004 Nov-Dec;22(6):343-52