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But Melanotan II has been linked to some serious side effects including kidney failure, nausea, skin flushing, skin cancer, and potential cardiovascular issues

When tyrosinase is less abundant, the production of melanin is impeded, resulting in less skin pigmentation

This contrasts with synthetic drugs that may accumulate or produce active metabolites

10.1016/S0165-3806(97)00108-9 [DOI] [PubMed] [Google Scholar] Akimoto M., Baba A., Ikeda-Matsuo Y., Yamada M

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Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial