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the highest concentration of glutathione is found in the liver*

While DN can develop at any age, older individuals may exhibit heightened susceptibility to this condition due to a history of inadequate glycemic control and the presence of multiple comorbidities (Narasimhan et al., 2021)

Regulating TAM iron metabolism within the TIME, specifically by promoting iron uptake and storage in M2-type macrophages while inhibiting iron release, allows iron accumulation in TAMs to enhance ROS production, increase p300/CBP acetyltransferase activity, and promote p53 acetylation

Moreover, early studies on HIV-1-infected subjects associated GSH deficiency with a poor lymphocytic response and impaired survival following HIV-1 infections 28,29,30 , implying a role for GSH in disease

Development and evaluation of methotrexate and baicalin-loaded nanolipid carriers for psoriasis treatment

10.1158/1078-0432.CCR-08-0230 80