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NNMT plays a critical role in regulating nicotinamide metabolism and acts as a key modulator of NAD availability within cells

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Downstream transcription factors showed dramatic upregulation: c-Fos by 4.99-fold, c-Jun by 7.05-fold, and Egr-1 by 3.70-fold

These factors collectively suggest that the conclusions, while robust, should be interpreted with caution in clinical decision-making

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