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Inhibition of AKT (a serine/threonine protein kinase) activation and blockade of the PI3K/AKT pathway can increase the activity of HK2 in aerobic glycolysis, thereby delaying joint inflammation and restoring cartilage homeostasis in OA cartilage

The study sought to clarify whether AOD-9604 produced its reported fat-reducing effects through the same receptor pathway as native growth hormone, and whether the 3-AR pathway was required for activity

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The function of ATPase copper transporter ATP7B in intestine

Watanabe T, Miyazaki A, Katagiri T, Yamamoto H, Idei T, Iguchi T

Mice heterozygous for a disrupted UA oxidase transgene (UO X +/) exhibited diminished brain damage and enhanced functional recovery following ischemic stroke, prompted researchers to explore the potential role of UA treatment in animal stroke models [145]