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DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids

This mechanism dramatically increases phosphorylation of focal adhesion kinase and paxillin proteins without changing total protein amounts[6]

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But they come with a caveat that rarely gets the attention it deserves: up to 30 to 40% of that weight loss can come from lean muscle mass rather than fat tissue