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MS spectra of MK4 incubated with recombinant human FSP1 (rhFSP1) and/or NADH detected by MS

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Endotoxin tests further showed that long-term exposure impaired TNF- reactivity, suggesting cumulative NSW increases inflammation-related disease risk, including cancer 31

Proposed mechanisms include phage modulation, activation of the BA-FXR-fibroblast growth factor 19 (FGF19) axis, restoration of gut barrier integrity, and enhanced production of beneficial microbial metabolites such as short-chain fatty acids (SCFAs) 180,181