10.1016/j.fsi.2013.03.365 Fish Shellfish Immunol
This aspect is of particular interest for research on metabolic disorders and energy balance
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More significantly, the acute application of AngIV or one of its analogs, Nle-Tyr-Ile-His-Pro-Phe (Nle 1 -AngIV), reverses deficits in dementia models induced by 1) treatment with the cholinergic muscarinic receptor antagonist scopolamine (Pederson et al., 2001), 2) kainic acid injections into the hippocampus (Stubley-Weatherly et al., 1996), 3) perforant path cuts (Wright et al., 1999), and 4) ischemia resulting from transient four-vessel occlusion (Wright et al., 1996)
yet, most peptides that were originally considered to be exclusively synthesized in the periphery are now also known to be generated in the central nervous system (CNS)
