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VDAC phosphorylation, a lipid sensor influencing the cell fate

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Neurological Protection and Brain Health The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption, abundant polyunsaturated fatty acids susceptible to lipid peroxidation, and relatively modest intrinsic antioxidant defences

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The main ongoing studies: REDEFINE 1 , Phase 3 obesity without T2D (results 20242025, preliminarily 25.3 %) REDEFINE 2 , Phase 3 obesity + T2D REDEFINE 3 , Phase 3 cardiovascular outcome trial (n~7000) Stand-alone clinical development of Cagrilintide is limited , Novo Nordisk is primarily investing in the CagriSema combination

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