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The short half-life of the active peptide in the body is separate from solution stability, but degradation in the vial is still a concern
Although GSH may act as a backup for TrxR to keep Trx in its reduced form 36 , it will be depleted by APR-246, leading to the dramatically increased ROS production due to the simultaneous inactivation of both major redox systems
More than 95% of L-Carnitine stores are contained in muscles, along with trace amounts in the liver & kidneys
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