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In addition, it is possible that evolution led to shared redox-sensing channels (e.g., Hyperkinetic and Shaker) to mechanically link sleep-active neurons and redox metabolism in order to more efficiently serve a common fundamental need

A reduction in NAD+ levels has been associated with various metabolic disorders (Sara et al., 2021), underscoring its importance in cellular homeostasis

Its cognition-enhancing effects may be due to an ability to influence the brains levels of noradrenaline, serotonin, and dopamine,4 three neurotransmitters with well-documented relationships to vigilance, attention, learning,5 memory,6 and the motivation toward cognitive effort.7 Meanwhile, its anxiolytic effects appear to be GABAergic (i.e., relating to the neurotransmitter GABA)

EMBO J 6: 139144

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