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Gastrointestinal events were the most common adverse effect, dose-related and mostly mild to moderate, eased by starting low

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10.1007/164_2020_404 6 BersonA.NativioR.BergerS

The insulin secreting -cells, in contrast to the liver, do not express the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) but do express robust levels of the gluconeogenic enzyme pyruvate carboxylase (PC)

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