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Applicable Equation Assuming a drug is completely absorbed from the gastrointestinal tract (i.e., the fraction absorbed, f a , is 1), its oral bioavailability (F) is determined entirely by the fraction that escapes hepatic extraction

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stiffness and resistance to limb movement caused by increased muscle tone and/or an excessive and continuous contraction of muscles, which may be uniform (lead-pipe rigidity) or ratchety (cogwheel rigidity), and which may be associated with joint pain

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