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Among them, diacylglycerol activates PKC and impairs IRS-1 activation, while ceramides activate protein kinase C zeta (PKC) and protein phosphatase 2A (PP2A), resulting in dephosphorylation of Akt, 31,32 and promoting gluconeogenesis
Molecular pharmacology of topiramate: Managing seizures and preventing migraine
Phytomedicine 10:7479 Shen X, Shi H, Chen X, Han J, Liu H, Yang J, Shi Y, Ma J (2023) Esculetin alleviates inflammation, oxidative stress and apoptosis in intestinal ischemia/reperfusion injury via targeting SIRT3/AMPK/mTOR signaling and regulating
Furthermore, TNF- affects the expression of the GPX4 protein and regulates the potential ferroptosis state of cells