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found that capsaicin could significantly activate TRPV1 and inhibit poldip2 and NADPH oxidase (Nox)4 under high glucose environment

Boehme, M

2018;11 doi: 10.1177/1178646918776658

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HC neutrophils were cultured in the presence of HC or SLE serum with or without the addition of Cl-amidine (Cl) (peptidyl arginine deiminase 4 (PAD4) inhibitor, 100 M), or LPX-1 (1 M) for 4 or 16 hours and NETs were assessed in SYTOX Green+ cells based on morphology (n = 6)

Arterioscler Thromb Vasc Biol 24(2):313319