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doi: 10.1021/bm201098j [DOI] [PubMed] [Google Scholar] 184.Urban P, Jose Valle-Delgado J, Moles E, Marques J, Diez C, Fernandez-Busquets X

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For example, pH-sensitive nanoparticles achieve passive targeting through the EPR effect (enhanced permeability and retention effect) in pancreatic cancer models, significantly enhancing drug delivery and reducing toxicity (Yetisgin et al., 2020)

Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis