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By restoring GH pulsatility, sermorelin may improve bone mineral density and structural integrity, helping reduce fracture risk and allowing patients to maintain active lifestyles with fewer limitations
423,424 In addition, insulin and IGF1 inhibit sex-hormone binding globulin (SHBG) synthesis, although both hormones stimulate ovarian synthesis of sex steroids that can promote cellular proliferation and inhibit apoptosis in breast epithelium and endometrium