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Standalone 5-Amino-1MQ without dietary or pharmacological caloric reduction will have more modest effects

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This is fibroblast activation translating into early collagen deposition

The transcriptional regulator STAT3 elicits PINK1-dependent mitophagy, which eliminates dysfunctional mitochondria, reverses the collapse of the mitochondrial membrane potential, and represses mtROS release and NLRP3 inflammasomes, whilst STAT3 downregulation protects against osteoclastogenesis (156)

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