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2004;82 Suppl 3:10591066

In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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Development of therapeutic protein biosimilars: comparative analytical assessment and other quality-related considerations

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