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The 25 mg dose produces larger IGF-1 increases but also more side effects, including fluid retention, increased appetite, and mild transient insulin resistance

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ASK1 goes on to bind to TRAF2, which in turn activates downstream-signaling cascades, including the MKK3/4/6p38 and MKK4/7JNK signaling pathways 36,37 (Figure 4)

In Vivo biodistribution and tumor targeting Establishment of subcutaneous and orthotopic pancreatic cancer models A subcutaneous pancreatic cancer model was established by injecting a BxPC-3 cell suspension (1 10 6 cells) into the right axilla of two BALB/c-nu mice